Nanotoxicity: Must Consider Aspect of Nanoparticle Development

Early years are proof of nanoparticle developments and understanding basic mechanisms. With no doubt, nanotechnology-based drug delivery systems are very effective to achieve improved therapeutic effects in vivo and properties in vitro. Drug discovery programs are generating pharmacologically potential drugs but they suffer from solubility, stability, and toxicity. Nanoparticle engineering could find various solutions to solve these issues but unknowingly it contributes to the toxicity at cellular and organ levels. New ways to treat diseases are being researched include approaches like gene therapy and immunotherapy, which suffer from other formulation disadvantages and toxicity issues. Overall, many exciting results are obtained using nanotechnology research in various infectious and non-infectious diseases. However, main challenges remain is to pass safety testing during preclinical and clinical trial. Nanotechnology in health care system is growing rapidly and needs attention from scientists in finding suitable toxicological assays and analysis methods.

https://doi.org/10.1007/978-3-319-11728-7_6