The development and characterization of lipid nanoparticle of stavudine with robust particle size control, stability and superior targeting of antiretroviral drug molecules is reported. The blood clearance, lymph kinetic, gamma imaging and biodistribution for radiolabeled pure drug, blank and drug loaded nanoparticles were carried out in rats. The prepared lipid nanoparticles showed enhanced levels in major HIV reservoir sites in body. Macrophage uptake study revealed the potential of prepared lipid nanoparticles for targeting intracellular compartments and eradication of viral load from the cellular and anatomical reservoir sites focusing on the
https://pubmed.ncbi.nlm.nih.gov/21612153/
