Flavonoids have many positive effects on various cell layers of the skin (e.g., anti-oxidant, anti-allergic and anti-inflammatory effects). However, the limiting factor of the use of flavonoids is their low water solubility. To overcome the low solubility, apigenin nanosuspensions were prepared using the combination technology (CT), i.e., bead milling and subsequently high-pressure homogenization. Distinct reduction in particle size was observed after each bead milling passage resulting in z-average (PCS) of 413 nm and a polydispersity index of 0.202. The developed smartCrystals can be easily incorporated into gels, which makes apigenin nanocrystals available for dermal application as efficient antioxidant.