Advancement in cancer research and therapies is fastened by possibilities of record-breaking technologies and its applications. Lot of limitations like drug properties, industrial scale up and stability and clinical still hinder the path of drug candidates to clinical trial. However, collaboration of clinicians with research scientist, chemist, and academia is adding value to the new research developments. Nanoparticles are definitely an ideal drug delivery system which offers numerous advantages over conventional dosage forms and can direct drug to specific site or organ in body. Other therapies like radiation, phototherapy, and siRNA delivery are advancing rapidly and studied widely.